home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410p.zip
/
M94A3003.TXT
< prev
next >
Wrap
Text File
|
1994-10-25
|
3KB
|
41 lines
Document 3003
DOCN M94A3003
TI HIV-related non Hodgkin lymphomas (NHL): report of 53 cases.
DT 9412
AU Schlacht I; Landonio G; Nosari AM; Caggese L; Orso M; Schiantarelli C;
Dept. of Infectious Diseases, Niguarda Hospital, Milan, Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):176 (abstract no. PB0129). Unique
Identifier : AIDSLINE ICA10/94369572
AB OBJECTIVE: to evaluate retrospectively 53 cases of HIV-related NHL,
followed in our Department in the period 1986-1993. ANALYSIS OF CASES:
43 were males, 10 females. Median age was 30 yrs (r. 26-54). CD4+ were <
0.1 x 10E9 g/l in 43 cases; at diagnosis opportunistic infections were
present in 37 cases. 23 (43%) were primary cerebral lymphomas (PCL);
only 10 (19%) were lymphonodal at onset; 20 (38%) were extranodal (4
cutaneous, 3 lungs, 2 bone marrow, 2 gastroenteric, 1 breast, 1 tongue,
7 plurivisceral). The diagnosis was bioptic in 24 cases; autoptic in 29
(20/23 PCL). Histology, according to WF: high malignancy in all PCL; in
other cases: 22 high (4 G, 3 H, 1 I, 1 J, 9 K, 4 Ki-1) and 8
low-intermediate malignancy (2 C, 4 F, 1 AILD-T, 1 T cutaneous). 50/53
cases showed B immunophenotype. Median follow-up was 5 months (r: 1-38).
Only 9 patients are still alive. Median overall survival (MOS) was 2
months in PCL (r: 1-4) and 7 months in other cases (r. 1-38).
Chemotherapy (CHOP cycles) was performed in 14 cases (MOS of treated
patients: 7 months); radiotherapy in 7 (6/7 PCL). 1 patient had
associated Kaposi's Sarcoma. CONCLUSION: 1) PCL were the most frequent
sites of onset of HIV-related NHL; 2) other extranodal lymphomas were
very frequent, with some unusual sites of onset (breast, tongue); 3)
histology was high malignancy in a high percentage of cases (84%); 4)
the course was aggressive in the majority; MOS was low even in treated
patients; longer survival was seen only in low-intermediate malignancy.
DE Adult AIDS-Related Opportunistic Infections/DIAGNOSIS/MORTALITY/THERAPY
Brain Neoplasms/DIAGNOSIS/MORTALITY/THERAPY Combined Modality Therapy
Female Follow-Up Studies Human HIV
Infections/*DIAGNOSIS/MORTALITY/THERAPY Lymphoma,
AIDS-Related/*DIAGNOSIS/MORTALITY/THERAPY Male Middle Age
Retrospective Studies Survival Rate MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).